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ICA-110381
- Soluble in DMSO
- MF: C12H8Cl2N2O
- MW: 267.11
Description
ICA-110381 is a Kv7.2/Kv7.3 (KCNQ2/Q3) potassium channel opener with an EC50 value of 0.38 μM. ICA-110381 predominantly acts on KCNQ2-containing channels, shapes resonance and network oscillations in vitro and show anticonvulsant potential in vivo without affecting spontaneous synaptic transmission in the rat hippocampus in vitro.
More Information
| Parent CAS No. | 325457-99-6 |
|---|---|
| Chemical Name | 4-Chloro-N-(6-chloropyridin-3-yl)benzamide |
| SMILES | C1(Cl)C=CC(C(NC2C=CC(Cl)=NC=2)=O)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C12H8Cl2N2O/c13-9-3-1-8(2-4-9)12(17)16-10-5-6-11(14)15-7-10/h1-7H,(H,16,17) |
| InChiKey | FOYOGIUAMYSVIT-UHFFFAOYSA-N |
| CID | 4314115 |
| Short Description | KCNQ channel opener |
References
- A Boehlen et al. The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. Br J Pharmacol. 2013 Mar;168(5):1182-200.
- G Amato et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.
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