ICA-110381 is a Kv7.2/Kv7.3 (KCNQ2/Q3) potassium channel opener with an EC50 value of 0.38 μM. ICA-110381 predominantly acts on KCNQ2-containing channels, shapes resonance and network oscillations in vitro and show anticonvulsant potential in vivo without affecting spontaneous synaptic transmission in the rat hippocampus in vitro.

KEYWORDS: ICA-110381 | supplier | KCNQ channel opener | ICA110381 | ICA 110381 | CAS [325457-99-6] | Potassium | Kv7.2 | Kv7.3 | Opener | Ion Channels | Anti-convulsant