TAS-103 dihydrochloride is an anticancer agent targeting topoisomerases I and II with IC50 values of 2 µM and 6.5 µM, respectively. Moreover, TAS-103 dihydrochloride has a strong cytotoxic effect on P388 and KB cells with IC50 values of 0.0011 µM and 0.0096 µM, respectively. Also, TAS-103 has strong inhibitory effects on the growth of various mouse and human solid tumors in vivo, as well as high antitumor activity against lung metastatic cancer.

KEYWORDS: TAS-103 dihydrochloride | supplier | Topo 1/2 inhibitor | BMS 247615 dihydrochloride | TAS-103 | TAS103 | BMS247615 | BMS-247615 | CAS [174634-08-3] | CAS [174634-09-4] | DNA-RNA | TOPO | Inhibitor | Enzymes | Topoisomerase | Lung cancer