Bulk Inquiry
TAS-103 dihydrochloride
- BMS 247615 dihydrochloride
- Parent CAS: 174634-08-3
- Soluble in water and DMSO
- MF: C20H19N3O2.2HCl
- MW: 406.31
Description
TAS-103 dihydrochloride is an anticancer agent targeting topoisomerases I and II with IC50 values of 2 µM and 6.5 µM, respectively. Moreover, TAS-103 dihydrochloride has a strong cytotoxic effect on P388 and KB cells with IC50 values of 0.0011 µM and 0.0096 µM, respectively. Also, TAS-103 has strong inhibitory effects on the growth of various mouse and human solid tumors in vivo, as well as high antitumor activity against lung metastatic cancer.
More Information
| Parent CAS No. | 174634-08-3 |
|---|---|
| Chemical Name | 6-(2-(Dimethylamino)ethylamino)-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride |
| SMILES | C1C2N=C(NCCN(C)C)C3C(=O)C4C=CC=CC=4C=3C=2C=CC=1O.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C20H19N3O2.2ClH/c1-23(2)10-9-21-20-18-17(13-5-3-4-6-14(13)19(18)25)15-8-7-12(24)11-16(15)22-20;;/h3-8,11,24H,9-10H2,1-2H3,(H,21,22);2*1H |
| InChiKey | HAYAYGFVSIWSGQ-UHFFFAOYSA-N |
| CID | 135413532 |
| Short Description | Topo 1/2 inhibitor |
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