AC 264613 is a potent, selective, and metabolically stable protease activated receptor 2 (PAR2) agonist (pEC50 value of 6.7). The potency of AC 264613 in the cellular proliferation assay was approximately 50 nM, and was virtually the same at wild-type PAR2 receptors. Incubation of macrophages with AC 264613 caused a decrease of IRF5 expression and also significantly reduced p53 protein expression.

KEYWORDS: AC 264613 | supplier | PAR2 agonist | AC-264613 | AC264613 | CAS [1051487-82-1] | Thrombin | Thrombin (PAR) | Agonist | Receptors