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STF 62247
- Soluble in DMSO
- MF: C15H13N3S
- MW: 267.35
Description
STF 62247 selectively targets VHL-deficient renal cell carcinoma (RCC) cells (IC50 value of 0.625 µM in RCC4). STF 62247-stimulated toxicity occurs in a HIF-independent manner through autophagy. Moreover, STF 62247 induced apoptotic and autophagic cell death in leukemic cells.
More Information
| Parent CAS No. | 315702-99-9 |
|---|---|
| Chemical Name | 4-(Pyridin-4-yl)-N-m-tolylthiazol-2-amine |
| SMILES | N1C=CC(C2N=C(NC3C=C(C)C=CC=3)SC=2)=CC=1 |
| MFCD | MFCD01121974 |
| InChi | InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18) |
| InChiKey | KATNUHQNJGNLPW-UHFFFAOYSA-N |
| CID | 704473 |
| Short Description | Inducer of apoptosis and autophagy |
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