Bulk Inquiry
CP 31398
- Parent CAS: 259199-65-0
- Soluble in water and DMSO
- MF: C22H28Cl2N4O
- MW: 435.39
Description
CP 31398 stabilizes the core domain of the tumour suppressor p53 in vitro and is an effective anti-cancer drug by virtue of rescuing destabilized mutants of p53. Moreover, CP 31398 can induce apoptosis of human cancer cells.
More Information
| Parent CAS No. | 259199-65-0 |
|---|---|
| Chemical Name | (E)-N1-(2-(4-methoxystyryl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine dihydrochloride |
| SMILES | C12C=CC=CC=1N=C(/C=C/C1C=CC(OC)=CC=1)N=C2NCCCN(C)C.Cl.Cl |
| MFCD | MFCD17215956 |
| InChi | InChI=1S/C22H26N4O.2ClH/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H/b14-11+;; |
| InChiKey | WWIFDJIOGCGSBS-IVKCLRODSA-N |
| CID | 56972205 |
| Short Description | p53 stabilizer |
References
- BA Foster et al. Pharmacological rescue of mutant p53 conformation and function. Science. 1999 Dec 24;286(5449):2507-10.
- TM Rippin et al. Characterization of the p53-rescue drug CP-31398 in vitro and in living cells. Oncogene. 2002 Mar 28;21(14):2119-29.
- R Takimoto et al. The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. Cancer Biol Ther. 2002 Jan-Feb;1(1):47-55.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1402 | NSC 348884 |
From $132.00 |
| 1871 | Pifithrin-α hydrobromide |
From $104.50 |
| 2016 | NSC 319726 |
From $104.50 |
| 2244 | SCH 529074 |
From $132.00 |
| 2249 | Tenovin 6 |
From $115.50 |
| 2319 | L 002 |
From $88.00 |
| 2564 | NSC 59984 |
From $104.50 |
| 2841 | COTI-2 |
From $137.50 |
| 3051 | Pifithrin-β |
From $104.50 |
| 3152 | PAWI-2 |
From $132.00 |
| 3277 | NSC194598 |
From $143.00 |
| 4278 | Pifithrin-μ |
From $104.50 |
Other Categories
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.