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RAF709
- Soluble in DMSO
- MF: C28H29F3N4O4
- MW: 542.55
Description
RAF709 is a potent, selective, and efficacious B/C RAF inhibitor with IC50 values of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively. RAF709 was cellularly potent in a KRAS mutant cell line (Calu-6) and was well-tolerated and efficacious in KRAS mutant xenograft models.
More Information
| Parent CAS No. | 1628838-42-5 |
|---|---|
| Chemical Name | N-(2-Methyl-5'-morpholino-6'-(tetrahydro-2H-pyran-4-yloxy)-3,3'-bipyridin-5-yl)-3-(trifluoromethyl)benzamide |
| SMILES | C1(N2CCOCC2)C=C(C2C(C)=NC=C(NC(C3C=CC=C(C(F)(F)F)C=3)=O)C=2)C=NC=1OC1CCOCC1 |
| MFCD | MFCD30534393 |
| InChi | InChI=1S/C28H29F3N4O4/c1-18-24(15-22(17-32-18)34-26(36)19-3-2-4-21(13-19)28(29,30)31)20-14-25(35-7-11-38-12-8-35)27(33-16-20)39-23-5-9-37-10-6-23/h2-4,13-17,23H,5-12H2,1H3,(H,34,36) |
| InChiKey | FYNMINFUAIDIFL-UHFFFAOYSA-N |
| CID | 90408826 |
| Short Description | B/C RAF inhibitor |
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