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AG-120
- Ivosidenib
- Optical Purity: 99.9% e.e.
- Soluble in DMSO
- MF: C28H22ClF3N6O3
- MW: 582.96
Description
AG-120 (Ivosidenib) is an oral, selective, first-in-class, potent inhibitor of mutant IDH1. Treatment with AG-120 decreased intracellular 2-HG levels, inhibited growth factor independent proliferation and restored erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provided an effective way to lower intracellular 2-HG levels and induced myeloid differentiation.
More Information
| Parent CAS No. | 1448347-49-6 |
|---|---|
| Chemical Name | (S)-N-((S)-1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
| SMILES | C1C(N(C([C@@H]2CCC(=O)N2C2N=CC=C(C#N)C=2)=O)[C@H](C(NC2CC(F)(F)C2)=O)C2C=CC=CC=2Cl)=CN=CC=1F |&1:4,19,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1 |
| InChiKey | WIJZXSAJMHAVGX-DHLKQENFSA-N |
| CID | 71657455 |
| Short Description | IDH1 inhibitor |
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