AG-120 (Ivosidenib) is an oral, selective, first-in-class, potent inhibitor of mutant IDH1. Treatment with AG-120 decreased intracellular 2-HG levels, inhibited growth factor independent proliferation and restored erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provided an effective way to lower intracellular 2-HG levels and induced myeloid differentiation.

KEYWORDS: AG-120 | supplier | IDH1 inhibitor | Ivosidenib | AG120 | AG 120 | CAS [1448347-49-6] | Isocitrate | IDH | Inhibitor | Enzymes