AG-120 - Ivosidenib

Based on 11 reference(s) in Google Scholar 8 10 11

Axon 2746

CAS [1448347-49-6]

MF C28H22ClF3N6O3
MW 582.96

  • Purity: 99%
  • Optical purity: 99.9% e.e.
  • Soluble in DMSO
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AG-120

Description

AG-120 (Ivosidenib) is an oral, selective, first-in-class, potent inhibitor of mutant IDH1. Treatment with AG-120 decreased intracellular 2-HG levels, inhibited growth factor independent proliferation and restored erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provided an effective way to lower intracellular 2-HG levels and induced myeloid differentiation.

KEYWORDS: AG-120 | supplier | IDH1 inhibitor | Ivosidenib | AG120 | AG 120 | CAS [1448347-49-6] | Isocitrate | IDH | Inhibitor | Enzymes

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10 mg €125.00 In Stock
50 mg €375.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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