The IκB kinase-β (IKKβ or IKK-2) inhibitor IMD-0354 inhibited nuclear translocation of NF-κB induced by TNF-α; this attenuated myocardial reperfusion injury and preserved cardiac function after myocardial infarction. TNF-α-induced production of interleukin-1β and monocyte chemoattractant protein-1 was reduced significantly by IMD-0354. IMD-0354 restrained proliferation of mast cells with c-kit mutations and suppressed the growth of human breast cancer cells by arresting cell cycle at the G0-G1 phase and inducing apoptosis. May effectively prevent restenosis.

KEYWORD: IMD-0354 | supplier | IKK-2 inhibitor | IMD0354 | IMD 0354 | CAS [978-62-1] | IκB | IKK | Inhibitor | Enzymes | IκB kinase-β | NF-κB | TNF-α | restenosis | breast cancer