Based on 57 reference(s) in Google Scholar 8 10 57

Axon 2725

CAS [978-62-1]

MW 383.67

  • Purity: 99%
  • Soluble in 0.1N NaOH(aq) and DMSO



The IκB kinase-β (IKKβ or IKK-2) inhibitor IMD-0354 inhibited nuclear translocation of NF-κB induced by TNF-α; this attenuated myocardial reperfusion injury and preserved cardiac function after myocardial infarction. TNF-α-induced production of interleukin-1β and monocyte chemoattractant protein-1 was reduced significantly by IMD-0354. IMD-0354 restrained proliferation of mast cells with c-kit mutations and suppressed the growth of human breast cancer cells by arresting cell cycle at the G0-G1 phase and inducing apoptosis. May effectively prevent restenosis.

KEYWORD: IMD-0354 | supplier | IKK-2 inhibitor | IMD0354 | IMD 0354 | CAS [978-62-1] | IκB | IKK | Inhibitor | Enzymes | IκB kinase-β | NF-κB | TNF-α | restenosis | breast cancer

Size Unit Price Stock
10 mg €90.00 In Stock
50 mg €290.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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