Bulk Inquiry
YUKA1
- Soluble in DMSO
- MF: C13H16N4O2S
- MW: 292.36
Description
YUKA1 is a potent, cell-permeable, and selective inhibitor of the histone demethylase KDM5A (IC50 = 2.66 µM). Mechanistically, it blocks KDM5A activity to increase cellular levels of trimethylated histone H3 lysine 4 (H3K4me3), which restores active gene transcription. In oncology research, YUKA1 effectively suppresses cell proliferation and blocks the emergence of drug-tolerant persister (DTP) cells in lung and breast cancers, overcoming resistance to targeted therapies.
Key Features
- Specifically targets the KDM5A histone demethylase enzyme
- IC50: 2.66 µM
- Cell permeable: Readily enters intact cells to modify nuclear chromatin.
- Epigenetic Protection: Prevents demethylation to maintain active H3K4me3 marks.
Applications
- KDM5A and histone demethylase research
- H3K4 methylation and chromatin regulation
- Epigenetic mechanisms of drug resistance
- Breast and cervical cancer cell studies
More Information
| Parent CAS No. | 708991-09-7 |
|---|---|
| Chemical Name | 4-(2-(Allyloxy)-3-methoxybenzylamino)-4H-1,2,4-triazole-3-thiol |
| SMILES | C1(OC)C(OCC=C)=C(CNN2C=NN=C2S)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C13H16N4O2S/c1-3-7-19-12-10(5-4-6-11(12)18-2)8-15-17-9-14-16-13(17)20/h3-6,9,15H,1,7-8H2,2H3,(H,16,20) |
| InChiKey | NHJCZZWENDYDEP-UHFFFAOYSA-N |
| CID | 2215170 |
| Short Description | KDM5A inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1933 | GSK J4 |
From $115.50 |
| 1934 | GSK J1 |
From $115.50 |
| 2077 | OG-L002 hydrochloride |
From $137.50 |
| 2081 | ML 324 dihydrochloride |
From $99.00 |
| 2160 | JIB 04 |
From $99.00 |
| 2306 | Bizine |
From $132.00 |
| 2375 | GSK-LSD1 |
From $110.00 |
| 2573 | CPI 455 |
From $104.50 |
| 2622 | CPI 4203 |
From $93.50 |
| 2809 | KDM5 inhibitor compound 48 |
From $159.50 |
| 3783 | JQKD82 dihydrochloride |
From $209.00 |
