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Axon 2674
CAS [708991-09-7]
MF C13H16N4O2SMW 292.36
YUKA1 is a cell-permeable selective inhibitor of lysine demethylase 5A (KDM5A/RBP2/JARID1A) (IC50 value 2.66 μM). YUKA1 blocks drug resistance and cancer cell growth in HeLa cervical cancer cells and ZR-75-1 breast cancer cells. YUKA1 was able to increase H3K4me3 levels in human cells and selectively inhibited the proliferation of cancer cells whose growth depends on KDM5A.
KEYWORDS: YUKA1 | supplier | KDM5A inhibitor | YUKA-1 | YUKA 1 | CAS [708991-09-7] | Histone | Histone demethylase | Inhibitor | Enzymes | KDM5A | RBP2 | JARID1A
4-(2-(Allyloxy)-3-methoxybenzylamino)-4H-1,2,4-triazole-3-thiol
[708991-09-7]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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