LP-935509

Based on 1 reference(s) in Google Scholar 9 10 1

Axon 2638

CAS [1454555-29-3]

MF C20H24N6O3
MW 396.44

  • Purity: 99%
  • Soluble in DMSO

LP-935509

Description

Potent, brain penetrant inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50 value 3.3 nM and 14 nM and 320 nM for the closely related BIKE and GAK enzymes, repsectively). LP-935509 is antinociceptive in multiple rat models of neuropathic pain, but not acute pain. The AAK1 inhibitor-induced antinociception and inhibition of spontaneous neural activity can be blocked by α2 adrenergic antagonists.

KEYWORDS: LP-935509 | supplier | AAK1 inhibitor | LP935509 | CAS [1454555-29-3] | AAK | neuropathic pain | adapter protein-2 | AP-2 | antinociceptive | nociception | SNF1 family | endocytosis | clathrin | Notch

Brain penetrant inhibitor of adapter protein-2 associated kinase 1 (AAK1)

Chemical name

isopropyl 4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

Parent CAS No.

[1454555-29-3]

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Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €450.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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