PBTZ169

Based on 93 reference(s) in Google Scholar 9 10 93

Axon 2626

CAS [1377239-83-2]

MF C20H23F3N4O3S
MW 456.48

  • Purity: 100%
  • Soluble in DMSO and Ethanol

PBTZ169

Description

Potent irreversible DprE1 inhibitor (MIC value <0.19 ng/mL and <0.004 µM against M. tuberculosis H37Ra) with improved stability against nitroreductase metabolism, and good efficacy at lower concentrations in the murine model of chronic tuberculosis (TB); an attractive drug candidate to treat TB in humans. The combination of PBTZ169, BDQ and pyrazinamide was found to be more efficacious than the standard three drug treatment in a murine model of chronic disease.

KEYWORDS: PBTZ169 | supplier | DprE1 inhibitor | PBTZ-169 | PBTZ 169 | CAS [1377239-83-2] | DPR | DprE | tuberculosis | TB | mycobacterium | flavo-enzyme | cell wall | biosynthesis | benzothiazinone | epimerase | Decaprenylphosphoryl-beta-D-ribofuranose

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5 mg €95.00 In Stock
25 mg €335.00 In Stock
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2 x 5 mg €150.00 In Stock
2 x 25 mg €500.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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