As the cell wall frames and protects mycobacterial cells, its biosynthesis is a fundamental process for the mycobacterial survival. As a consequence, the enzymes involved in this process represent potential drug targets in tuberculosis (TB) treatment. DprE1 (EC 1.1.98.3) is a decaprenylphosphoryl-D-ribose oxidase, involved in the biosynthesis of decaprenylphosphoryl-D-arabinose (DPA), an essential component of the mycobacterial cell wall. In concert with DprE2, it catalyses the epimerization of decaprenylphosphoryl-D-ribose (DPR) to DPA, via the formation of the intermediate decaprenylphosphoryl 2-keto-ribose (DPX)[1].