DprE

As the cell wall frames and protects mycobacterial cells, its biosynthesis is a fundamental process for the mycobacterial survival. As a consequence, the enzymes involved in this process represent potential drug targets in tuberculosis (TB) treatment. DprE1 (EC 1.1.98.3) is a decaprenylphosphoryl-D-ribose oxidase, involved in the biosynthesis of decaprenylphosphoryl-D-arabinose (DPA), an essential component of the mycobacterial cell wall. In concert with DprE2, it catalyses the epimerization of decaprenylphosphoryl-D-ribose (DPR) to DPA, via the formation of the intermediate decaprenylphosphoryl 2-keto-ribose (DPX)[1].


[1] G Riccardi et al. The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis. Appl Microbiol Biotechnol. 2013 Oct;97(20):8841-8.

2 Item(s)

per page
Axon ID Name Description From price
2698 BTZ043 Antimycobacterial DprE1 inhibitor that kills Mycobacterium tuberculosis  Recently added €105.00
2626 PBTZ169 Potent irreversible DprE1 inhibitor; tuberculosis therapeutic €95.00

2 Item(s)

per page
Please wait...