Bulk Inquiry
BTZ043
- BTZ10526043
Axon 2698
CAS:
1161233-85-7
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C17H16F3N3O5S
- MW: 431.39
Description
Antimycobacterial agent that kills Mycobacterium tuberculosis (MIC values 2.3 nM and 9.2 nM against M. tuberculosis H37Rv and M. smegmatis, respectively) in vitro, ex vivo, and in mouse models of TB through inhibition of decaprenylphosphoryl-b-D-ribose 2′-epimerase (DprE1).
More Information
| Parent CAS No. | 1161233-85-7 |
|---|---|
| Chemical Name | (S)-2-(2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one |
| SMILES | S1C2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2C(=O)N=C1N1CCC2(O[C@@H](C)CO2)CC1 |&1:23,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H16F3N3O5S/c1-9-8-27-16(28-9)2-4-22(5-3-16)15-21-14(24)11-6-10(17(18,19)20)7-12(23(25)26)13(11)29-15/h6-7,9H,2-5,8H2,1H3/t9-/m0/s1 |
| InChiKey | GTUIRORNXIOHQR-VIFPVBQESA-N |
| CID | 42609849 |
| Short Description | DprE1 inhibitor |
References
- V Makarov. Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science. 2009 May 8;324(5928):801-4.
- C Trefzer et al. Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1. J Am Chem Soc. 2012 Jan 18;134(2):912-5.
- SM Batt et al. Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11354-9.
Other Categories
Get a Quote for
Loading...
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.