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Axon 2593
CAS [276702-15-9]
MF C13H10Cl3N3O4SMW 410.66
Selective nonpeptide CXCR2 antagonist (IC50 values 9.3 nM and 9.6 µM for CXCR2 and CXCR1, respectively) exhibiting significant anti-inflammatory effects in acute and chronic models of arthritis in the rabbit. SB-332235 significantly reduced levels of proinflammatory mediators in the synovial fluid, including TNF-α, IL-8, PGE2, LTB4, and LTC4. SB-332235 was also found to abolish the GRO/CINC-1 mediated inhibition of C2-ceramide-induced cytochrome-c release from mitochondria.
KEYWORDS: SB 332235 | supplier | CXCR2 antagonist | SB332235 | SB-332235 | CAS [276702-15-9] | Chemokine | GPCR | anti-inflammatory | arthritis | TNF-α | IL-8 | interleukin-8 | PGE2 | prostaglandin | LTB4 | LTC4 | Alzheimer's | apoptosis
6-chloro-3-(3-(2,3-dichlorophenyl)ureido)-2-hydroxybenzenesulfonamide
[276702-15-9]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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