Locostatin - UIC 1005

Based on 102 reference(s) in Google Scholar 10 10 102

Axon 2590

CAS [90719-30-5]

MF C14H15NO3
MW 245.27

  • Purity: 100%
  • Optical purity: Optically pure
  • Soluble in DMSO and Ethanol



Non-toxic Raf kinase inhibitory protein (RKIP) inhibitor; disrupts the interaction of RKIP, not only with Raf-1 kinase, but also with GRK2; Locostatin is an inhibitor of cell sheet migration and cell growth in an epithelial cell proliferation assay, and it induced T cell anergy by blocking cytokine production after Ag recall. Other evidence suggested that Locostatin’s effects on cytoskeletal structure and migration are caused through mechanisms independent of its binding to RKIP and Raf/MAP kinase signaling.

KEYWORDS: Locostatin | supplier | RKIP/Raf inhibitor | UIC 1005 | UIC1005 | (N-crotonyl)-(4S)-isopropyl-2-oxazolidinone | (S)-(+)-4-benzyl-3-crotonyl-2-oxazolidinone | CAS [90719-30-5] | MAPK | MEK | RAF | Inhibitor | PEBP1 | Phosphatidylethanolamine Binding Protein | cell sheet migration | NF-kB | NIK | PKC | GPCR kinase 2

Size Unit Price Stock
10 mg €60.00 In Stock
50 mg €220.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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