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ML352
- VU0476201
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H29N3O4
- MW: 387.47
Description
Potent and selective inhibitor of the presynaptic choline transporter (CHT; Ki value 92 nM). ML352 exhibited no inhibition of acetylcholinesterase (AChE) or cholineacetyltransferase (ChAT) and also lacked activity at dopamine, serotonin, and norepinephrine transporters, as well as many receptors and ion channels.
More Information
| Parent CAS No. | 1649450-12-3 |
|---|---|
| Chemical Name | N-((3-isopropylisoxazol-5-yl)methyl)-4-methoxy-3-(1-methylpiperidin-4-yloxy)benzamide |
| SMILES | C(NCC1ON=C(C(C)C)C=1)(=O)C1=CC=C(OC)C(OC2CCN(C)CC2)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H29N3O4/c1-14(2)18-12-17(28-23-18)13-22-21(25)15-5-6-19(26-4)20(11-15)27-16-7-9-24(3)10-8-16/h5-6,11-12,14,16H,7-10,13H2,1-4H3,(H,22,25) |
| InChiKey | WBLVOWHFRUAMCP-UHFFFAOYSA-N |
| CID | 70679283 |
| Short Description | CHT inhibitor |
References
- SR Bollinger et al. Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1757-60.
- EA Ennis et al. Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. ACS Chem Neurosci. 2015 Mar 18;6(3):417-27.
- JL Bertron et al. Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4637-40.
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