GW 2580

Based on 266 reference(s) in Google Scholar 10 10 266

Axon 2571

CAS [870483-87-7]

MF C20H22N4O3
MW 366.41

  • Purity: 99%
  • Soluble in DMSO

GW 2580


An orally bioavailable inhibitor of c-FMS kinase (IC50 value of 0.03 µM in vitro) and the CSF1R receptor (Kd value 1.6 nM) that competitively blocks the ATP binding site of c-FMS. GW 2580 was inactive against 26 kinases in vitro and did not inhibit the growth of mouse NS0 lymphoblastoid cells, human fibroblasts, human endothelial cells, and five human tumor cell lines. GW 2580 also interacts with TrkA, TrkB, and TrkC (Kd values 630 nM, 36 nM, and 120 nM, respectively)

KEYWORDS: GW 2580 | supplier | dual cFMS kinase/CSF1R inhibitor | GW2580 | GW-2580 | CAS [870483-87-7] | FLT3LG | FMS | Inhibitor |RTK| c-FMS| CSF1R | FLT3 | ATP binding site | TrkA | TrkB | TrkC

Size Unit Price Stock
10 mg €75.00 In Stock
50 mg €225.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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