An orally bioavailable inhibitor of c-FMS kinase (IC50 value of 0.03 µM in vitro) and the CSF1R receptor (Kd value 1.6 nM) that competitively blocks the ATP binding site of c-FMS. GW 2580 was inactive against 26 kinases in vitro and did not inhibit the growth of mouse NS0 lymphoblastoid cells, human fibroblasts, human endothelial cells, and five human tumor cell lines. GW 2580 also interacts with TrkA, TrkB, and TrkC (Kd values 630 nM, 36 nM, and 120 nM, respectively)

KEYWORDS: GW 2580 | supplier | dual cFMS kinase/CSF1R inhibitor | GW2580 | GW-2580 | CAS [870483-87-7] | FLT3LG | FMS | Inhibitor |RTK| c-FMS| CSF1R | FLT3 | ATP binding site | TrkA | TrkB | TrkC