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CID 11654378
- FMS inhibitor compound 8 - FMS inhibitor compound 1b
Axon 2061
CAS:
885704-21-2
Purity:
99%
- Soluble in DMSO
- MF: C23H30N6O
- MW: 406.52
Description
CID 11654378 is a highly potent FMS/CSF1R receptor tyrosine kinase inhibitor with reported IC50 activity of 0.8 nM. It has been used as a proof-of-concept inhibitor in collagen-induced arthritis models.
FMS/CSF1R regulates macrophage survival, differentiation and inflammatory tissue remodeling. CID 11654378 is useful for studying CSF1R-dependent myeloid biology, inflammatory arthritis mechanisms and macrophage-targeted kinase pharmacology.
Key Features
- Potent FMS/CSF1R inhibitor
- Reported IC50: 0.8 nM
- Targets macrophage lineage signaling
- Active in reported collagen-induced arthritis models
Applications
- CSF1R kinase assays
- Macrophage signaling studies
- Inflammatory arthritis models
- Myeloid pathway pharmacology
More Information
| Parent CAS No. | 885704-21-2 |
|---|---|
| Chemical Name | 4-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl)-1H-pyrrole-2-carboxamide |
| SMILES | N1C=C(C#N)C=C1C(NC1=CC=C(N2CCN(C)CC2)C=C1N1CCC(C)CC1)=O |
| MFCD | MFCD22124465 |
| InChi | InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30) |
| InChiKey | DXPSQKSTVIVZLV-UHFFFAOYSA-N |
| CID | 11654378 |
| Short Description | FMS receptor tyrosine kinase inhibitor |
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