AZD 3759

Based on 62 reference(s) in Google Scholar 9 10 62

Axon 2563

CAS [1626387-80-1]

MF C22H23ClFN5O3
MW 459.90

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq) and DMSO

AZD 3759

Description

Potent, orally active, brain-penetrant, EGFR tyrosine kinase inhibitor (IC50 value 7.2 nM for inhibition of cellular phosphorylation on L858R cell lines), that shows tumor regression in the mouse model with brain metastasis. At 1 µM, AZD 3759 showed less than 50% inhibition against 115 out of a panel of 124 recombinant protein and lipid kinases, and was neither a direct inhibitor nor a time-dependent inhibitor for a series of Cytochrome isoforms, suggesting a low enzyme induction liability.

KEYWORDS: AZD 3759 | supplier | EGFR inhibitor | AZD3759 | CAS [1626387-80-1] | [1626387-81-2] | EGF | EGFR | Inhibitor | orally active | brain-penetrant | RTK | CNS | tumor regression | metastases | clinical trial | central nervous system

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Size Unit Price Stock
10 mg €85.00 In Stock
50 mg €255.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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