PFK 158

Based on 49 reference(s) in Google Scholar 9 10 49

Axon 2542

CAS [1462249-75-7]

MF C18H11F3N2O
MW 328.29

  • Purity: 99%
  • Soluble in DMSO

PFK 158

Description

Nanomolar small molecule inhibitor of PFKFB3 (IC50 value 137 nM) that is selectively cytotoxic to cancer cells and displays broad anti-tumor activity causing significant growth inhibition in preclinical models of breast, lung, glioblastoma, ovarian, pancreatic, melanoma and colon cancer. PFK158 is well tolerated in rats and dogs resulting in an acceptable pre-clinical therapeutic index.

KEYWORDS: PFK 158 | supplier | PFKFB3 inhibitor | PFK158 | CAS [1462249-75-7] | Fructose 6-phosphate | PFKFB3 | Inhibitor | glycolysis | solid malignancy | Ras | AKT | PI3K | p53 | PTEN | cytotoxic | cancer cells | anti-tumor activity | breast cancer | lung cancer | glioblastoma | ovarian cancer | pancreatic cancer | melanoma | colon cancer

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Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €475.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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