Nanomolar small molecule inhibitor of PFKFB3 (IC50 value 137 nM) that is selectively cytotoxic to cancer cells and displays broad anti-tumor activity causing significant growth inhibition in preclinical models of breast, lung, glioblastoma, ovarian, pancreatic, melanoma and colon cancer. PFK158 is well tolerated in rats and dogs resulting in an acceptable pre-clinical therapeutic index.

KEYWORDS: PFK158 | supplier | PFKFB3 inhibitor | PFK 158 | CAS [1462249-75-7] | Fructose 6-phosphate | PFKFB3 | Inhibitor | glycolysis | solid malignancy | Ras | AKT | PI3K | p53 | PTEN | cytotoxic | cancer cells | anti-tumor activity | breast cancer | lung cancer | glioblastoma | ovarian cancer | pancreatic cancer | melanoma | colon cancer