Omaveloxolone - RTA 408

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2497

CAS [1474034-05-3]

MF C33H44F2N2O3
MW 554.71

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in DMSO



Synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) and inhibits the proinflammatory transcription factor NF-κB at low concentrations. RTA 408 dose-dependently reduced NO concentrations (IC50 value 4.4 Nm). At higher concentrations, RTA 408 inhibited tumor cell growth (GI50 value 260 nM) and increased caspase activity in tumor cell lines, but not in normal primary human cells. RTA 408 is a highly effective mitigator of steady state hematopoiesis and shows normalization of the frequency of hematopoietic stem and progenitor cells in mice after administration of lethal, myeloablative doses of whole-body irradiation.

KEYWORDS: Omaveloxolone | Supplier | NRF2 acitivator | RTA 408 | RTA408 | RTA-408 | CAS [1474034-05-3] | DNA-RNA | NRF | Activator | Transcription Factors | NF-E2L2 | ROS | NO | nuclear factor erythroid 2-related factor 2 | JNK | NF-κB | inflammatory | radiation | mitigator | hematopoiesis

Size Unit Price Stock
2 mg €90.00 In Stock
5 mg €150.00 In Stock
25 mg €450.00 In Stock
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Size Unit Price Stock
2 x 5 mg €220.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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