Based on 83 reference(s) in Google Scholar 9 10 83

Axon 2484

CAS [756875-51-1]

MF C19H37NO4
MW 343.50

  • Purity: 98%
  • Soluble in DMSO



Sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, induces Akt phosphorylation in cultured osteoblasts, and protects them from Dex-induced apoptosis and necrosis. K6PC-5 acts to regulate both differentiation and proliferation of keratinocytes via [Ca2+]i responses through S1P production, which may represent a novel approach for treatment of skin disorders characterized by abnormal differentiation and proliferation, such as atopic dermatitis and psoriasis. Furthermore, a useful tool in animal or clinical studies for its antiglucocorticoids-associated osteonecrosis potential.

KEYWORDS: K6PC-5 | supplier | SphK1 activator | K6PC5 | CAS [756875-51-1] | Sphingosine | SphK | Activator | sphingosine-1-phosphate | S1P | apoptosis | necrosis | epidermal | differentiation | proliferation | keratinocytes | calcium signaling | dermatitis | psoriasis

Size Unit Price Stock
10 mg €105.00 In Stock
50 mg €305.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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