Sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, induces Akt phosphorylation in cultured osteoblasts, and protects them from Dex-induced apoptosis and necrosis. K6PC-5 acts to regulate both differentiation and proliferation of keratinocytes via [Ca²⁺]_i responses through S1P production, which may represent a novel approach for treatment of skin disorders characterized by abnormal differentiation and proliferation, such as atopic dermatitis and psoriasis. Furthermore, a useful tool in animal or clinical studies for its antiglucocorticoids-associated osteonecrosis potential.

KEYWORDS: K6PC-5 | supplier | SphK1 activator | K6PC5 | CAS [756875-51-1] | Sphingosine | SphK | Activator | sphingosine-1-phosphate | S1P | apoptosis | necrosis | epidermal | differentiation | proliferation | keratinocytes | calcium signaling | dermatitis | psoriasis