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DEAB
- NSC 8782
- Soluble in DMSO
- MF: C11H15NO
- MW: 177.24
Description
DEAB (NSC 8782) is a potent inhibitor of cytosolic class 1 aldehyde dehydrogenase (ALDH) enzymes, including ALDH1A isoforms. It is widely used to suppress retinoic acid biosynthesis and ALDH-dependent stem-cell phenotypes.
ALDH enzymes regulate aldehyde detoxification, retinoid metabolism, oxidative stress resistance and cancer stem-cell marker activity. DEAB is useful for studying ALDH1 function, retinoic acid signaling and ALDH-dependent differentiation or tumor biology.
Key Features
- Class 1 ALDH inhibitor
- Potent activity at ALDH1A1, ALDH1A2 and ALDH1A3 isoforms
- Suppresses retinoic acid biosynthesis from retinaldehyde
- Common tool for ALDH-positive stem and progenitor cell assays
Applications
- ALDH enzyme pharmacology
- Retinoic acid signaling research
- Cancer stem-cell and ALDH activity assays
- Developmental differentiation studies
More Information
| Parent CAS No. | 120-21-8 |
|---|---|
| Chemical Name | 4-(diethylamino)benzaldehyde |
| SMILES | C(=O)C1=CC=C(N(CC)CC)C=C1 |
| MFCD | MFCD00003382 |
| InChi | InChI=1S/C11H15NO/c1-3-12(4-2)11-7-5-10(9-13)6-8-11/h5-9H,3-4H2,1-2H3 |
| InChiKey | MNFZZNNFORDXSV-UHFFFAOYSA-N |
| CID | 67114 |
| Short Description | ALDH inhibitor |
References
- C.A. Morgan et al. N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes. Chem Biol Interact. 2015 Jun 5;234:18-28.
- M.I.Mahmoud et al. Effect of 4-(diethylamino)benzaldehyde on ethanol metabolism in mice. Alcohol Clin Exp Res. 1993 Dec;17(6):1223-7.
- M. Luo et al. Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1. ACS Chem Biol. 2015 Mar 20;10(3):693-7.
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