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KOTX1
Axon 3915
CAS:
1788963-83-6
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C17H16FN3O2
- MW: 313.33
Description
KOTX1 is a selective, non-cytotoxic and reversible ALDH1A3 inhibitor with a cellular IC50 value of 5.1 nM. KOTX1 improved glucose control, increased insulin secretion, and enhanced glucose tolerance.
More Information
| Parent CAS No. | 1788963-83-6 |
|---|---|
| Chemical Name | 3-Ethyl-N-(7-fluoro-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)isonicotinamide |
| SMILES | C1C(CC)=C(C(=O)NC2C(F)=CC3NC(=O)CCC=3C=2)C=CN=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H16FN3O2/c1-2-10-9-19-6-5-12(10)17(23)21-15-7-11-3-4-16(22)20-14(11)8-13(15)18/h5-9H,2-4H2,1H3,(H,20,22)(H,21,23) |
| InChiKey | QJJWNFKDFKNPEV-UHFFFAOYSA-N |
| CID | 86801883 |
| Short Description | ALDH1A3 inhibitor |
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