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Trelagliptin succinate
- SYR 111472 succinate - SYR 472
Axon 2470
- Parent CAS: 865759-25-7
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C18H20FN5O2.C4H6O4
- MW: 475.47
Description
Orally active DPP-4 inhibitor that produces clinically and statistically significant improvements in glycaemic control in patients with type 2 diabetes. SYR472 has a long duration of action and is well tolerated in clinical studies.
More Information
| Parent CAS No. | 865759-25-7 |
|---|---|
| Chemical Name | (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile succinate |
| SMILES | C(O)(=O)CCC(O)=O.C(#N)C1=CC=C(F)C=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1 |&1:31,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H20FN5O2.C4H6O4/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20;5-3(6)1-2-4(7)8/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3;1-2H2,(H,5,6)(H,7,8)/t15-;/m1./s1 |
| InChiKey | OGCNTTUPLQTBJI-XFULWGLBSA-N |
| CID | 44183569 |
| Short Description | DPP4 inhibitor |
References
- N. Inagaki et al. SYR-472, a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2014 Feb;2(2):125-32.
- K. V. T. S. Pavan Kumar et al. Study of plant glucosylxanthone & its analogs, as DPPIV inhibitor for anti-diabetic activity. Int. J. Pharm. Sci. Rev. Res., 15(1), 2012, 17, 83-87.
- A.J. Garber et al. The importance of incretin therapies for managing type 2 diabetes. Lancet Diabetes Endocrinol. 2014 Feb;2(2):95-7.
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