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UAMC-1110
- SP-13786
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C17H14F2N4O2
- MW: 344.32
Description
UAMC-1110 is a highly potent, selective and orally bioavailable FAP inhibitor with an IC50 value of 3.2 nM. UAMC-1110 shows high selectivity against the related dipeptidyl peptidases DPPIV, DPP9, DPPII, and prolyl oligopeptidase. Pharmacokinetic evaluation in mice demonstrated high oral bioavailability, plasma half-life, and the potential to selectively and completely inhibit FAP in vivo.
More Information
| Parent CAS No. | 1448440-52-5 |
|---|---|
| Chemical Name | N-(2-((S)-2-Cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl)-4-quinolinecarboxamide |
| SMILES | C1=C2C(C(=O)NCC(=O)N3CC(F)(F)C[C@H]3C#N)=CC=NC2=CC=C1 |&1:15,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H14F2N4O2/c18-17(19)7-11(8-20)23(10-17)15(24)9-22-16(25)13-5-6-21-14-4-2-1-3-12(13)14/h1-6,11H,7,9-10H2,(H,22,25)/t11-/m0/s1 |
| InChiKey | PUOOCZVRHBHJRS-NSHDSACASA-N |
| CID | 71621488 |
| Short Description | FAP inhibitor |
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