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Cuspin-1
- Soluble in DMSO
- MF: C13H10BrNO
- MW: 276.13
Description
Small molecule upregulator of the Survival of Motor Neuron protein (SMN; EC50 value 18 μM in SMA patient fibroblast cells); a tool compound that revealed that increasing Ras signaling upregulates SMN protein levels by increased phosphorylation of Erk, an important member of the Ras-Raf-MEK signaling cascade.
More Information
| Parent CAS No. | 337932-29-3 |
|---|---|
| Chemical Name | (5-bromopyridin-3-yl)(p-tolyl)methanone |
| SMILES | C(C1=CC(Br)=CN=C1)(C1=CC=C(C)C=C1)=O |
| MFCD | MFCD00452965 |
| InChi | InChI=1S/C13H10BrNO/c1-9-2-4-10(5-3-9)13(16)11-6-12(14)8-15-7-11/h2-8H,1H3 |
| InChiKey | AJZRSLVRFSCCIL-UHFFFAOYSA-N |
| CID | 2055944 |
| Short Description | SMN upregulator |
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