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FDI 6
- NCGC 00099374
Axon 2384
CAS:
313380-27-7
Purity:
99%
- Soluble in DMSO
- MF: C19H11F4N3OS2
- MW: 437.43
Description
Inhibitor of the Forkhead box protein M1 transcription factor (IC50 value 22.5 µM for inhibiting FOXM1-DNA binding). FDI6 displaces FOXM1 from genomic targets in MCF-7 breast cancer cells, and induces concomitant transcriptional downregulation. FDI-6 is inactive against the proteasome, and concordance between its biophysical IC50 and cellular GI50 values (22.5 μM and 18.0 μM, respectively) suggests it does not suffer from the off-target effects of thiostrepton.
More Information
| Parent CAS No. | 313380-27-7 |
|---|---|
| Chemical Name | 3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide |
| SMILES | C12C(N)=C(C(=O)NC3C=CC(F)=CC=3)SC=1N=C(C1SC=CC=1)C=C2C(F)(F)F |
| MFCD | MFCD01416826 |
| InChi | InChI=1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27) |
| InChiKey | ZATJMMZPGVDUOM-UHFFFAOYSA-N |
| CID | 5175738 |
| Short Description | FOXM1 inhibitor |
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