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ZLN 005
Axon 2379
CAS:
49671-76-3
Purity:
99%
- Soluble in DMSO
- MF: C17H18N2
- MW: 250.34
Description
ZLN 005 is a selective transcriptional regulator that stimulates PGC-1α expression and downstream metabolic genes in skeletal muscle cells. It increases glucose uptake and fatty-acid oxidation in L6 myotubes through an AMPK-dependent mechanism.
PGC-1α regulates mitochondrial biogenesis, oxidative metabolism and energy homeostasis. ZLN 005 is useful for studying transcriptional control of metabolic adaptation and skeletal-muscle pathways relevant to type 2 diabetes research.
Key Features
- Selective PGC-1α expression regulator
- Stimulates downstream oxidative metabolism genes
- Enhances glucose uptake and fatty-acid oxidation
- Acts through AMPK-dependent mechanisms in myotubes
Applications
- PGC-1α pathway research
- Skeletal muscle metabolism studies
- Glucose uptake assays
- Type 2 diabetes and mitochondrial biology models
More Information
| Parent CAS No. | 49671-76-3 |
|---|---|
| Chemical Name | 2-(4-tert-butylphenyl)-1H-benzo[d]imidazole |
| SMILES | C1(C2=CC=C(C(C)(C)C)C=C2)NC2=CC=CC=C2N=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19) |
| InChiKey | LQUNNCQSFFKSSK-UHFFFAOYSA-N |
| CID | 899323 |
| Short Description | Regulator of PGC-1α |
ZLN 005
selective transcriptional regulator
Regulator of PGC-1α
Supplier| Axon2379
ZLN005
PGC-1α
Type 2
T2DM
GLUT4
PGC-1α pathway research
Skeletal muscle metabolism studies
Glucose uptake assays
Type 2 diabetes and mitochondrial biology models
mitochondrial function
metabolism
diabetes research
receptor selectivity
transcriptional regulation
transcription
CAS 49671-76-3
Axon Medchem
Axon 2379
Supplier
Vendor
References
- L.N. Zhang et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013, 62, 1297-1307.
- L.N. Zhang et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One. 2013, 8, e72092.
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