BMS 833923 - XL 139

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2356

CAS [1059734-66-5]

MF C30H27N5O
MW 473.57

  • Purity: 99%
  • Soluble in DMSO

BMS 833923


Oral, small molecule antagonist of the Hedgehog (Hh) signaling component Smoothened (SMO). Treatment with BMS 833923 leads to a decreased expression of GLI1 and PTCH1 in EGI-1 cells, reduced tumor growth in vitro, and a prolongation of survival in vivo in different human cancers. Additionally, SMO inhibition by BMS 833923 leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells (EACs).

Size Unit Price Stock
5 mg €75.00 In Stock
25 mg €225.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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