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BMS 833923
- XL 139
- Soluble in DMSO
- MF: C30H27N5O
- MW: 473.57
Description
Oral, small molecule antagonist of the Hedgehog (Hh) signaling component Smoothened (SMO). Treatment with BMS 833923 leads to a decreased expression of GLI1 and PTCH1 in EGI-1 cells, reduced tumor growth in vitro, and a prolongation of survival in vivo in different human cancers. Additionally, SMO inhibition by BMS 833923 leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells (EACs).
More Information
| Parent CAS No. | 1059734-66-5 |
|---|---|
| Chemical Name | N-(2-methyl-5-((methylamino)methyl)phenyl)-4-(4-phenylquinazolin-2-ylamino)benzamide |
| SMILES | C(NC1=CC(CNC)=CC=C1C)(=O)C1=CC=C(NC2=NC(C3=CC=CC=C3)=C3C(=N2)C=CC=C3)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C30H27N5O/c1-20-12-13-21(19-31-2)18-27(20)33-29(36)23-14-16-24(17-15-23)32-30-34-26-11-7-6-10-25(26)28(35-30)22-8-4-3-5-9-22/h3-18,31H,19H2,1-2H3,(H,33,36)(H,32,34,35) |
| InChiKey | KLRRGBHZCJLIEL-UHFFFAOYSA-N |
| CID | 57662985 |
| Short Description | SMO antagonist |
References
- T.L. Lin et al. Hedgehog pathway as a drug target: Smoothened inhibitors in development. Onco. Targets Ther. 2012, 5, 47-58.
- J. Brechbiel et al. Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer. Cancer Treat. Rev. 2014, 40, 750-759.
- D. Riedlinger et al. Hedgehog pathway as a potential treatment target in human cholangiocarcinoma. J. Hepatobiliary Pancreat. Sci. 2014, 21, 607-615.
- A.H. Zaidi et al. Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells. Cancer Invest. 2013, 31, 480-489.
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