Roflumilast - Daxas | BY 217 | BYK 20869 | B 9302-107

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2352

CAS [162401-32-3]

MF C17H14Cl2F2N2O3
MW 403.21

Purity: 100%
Soluble in DMSO

Roflumilast

Description

First specific PDE4 inhibitor (IC50 value 0.2 - 4.3 nM for inhibition of PDE4 subtypes) licensed for the treatment of COPD.

K.F. Rabe et al. Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Br. J. Pharmacol. 2011, 163, 53-67.

W. Timmer et al. The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS-stimulated TNF-alpha ex vivo. J. Clin. Pharmacol. 2002, 42, 297-303.

L.A. Sorbera et al. Roflumilast: antiallergy/antiasthmatic, treatment of COPD, phosphodiesterase 4 inhibitor. Drugs Fut. 2000, 25, 1261-1264.

First specific PDE4 inhibitor licensed for treatment of COPD

Chemical name

3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

Parent CAS No.

[162401-32-3]

Order

Size	Unit Price	Stock
10 mg	€90.00	In Stock
50 mg	€280.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1127	L 454560	PDE4 inhibitor	Inquire
1168	Olprinone hydrochloride	PDE3 inhibitor	€119.00
1178	BAY 19-8004	PDE4 inhibitor	€160.00
1212	Rolipram	PDE4 inhibitor	€65.00
1216	Zardaverine	PDE3 and PDE4 inhibitor	€80.00
1229	(R)-(-)-Rolipram	PDE4 inhibitor	€110.00
1432	(S)-(+)-Rolipram	PDE4 inhibitor	€115.00
1592	SB 207499	PDE4 inhibitor	€70.00
1709	PDE5 inhibitor 42	PDE5 inhibitor	€125.00
1957	Apremilast	PDE4 inhibitor	€60.00
2046	Sildenafil citrate	Inhibitor of cGMP-specific PDE5	€75.00
2218	Gisadenafil besylate	Potent and selective inhibitor of PDE5	€120.00
2148	PF 04447943	Selective, brain penetrant PDE9A inhibitor	€70.00
2399	TAK 063	Highly potent, selective, and orally active PDE10A inhibitor	€110.00
2583	PXS 4728A	Potent inhibitor of VAP-1/SSAO inhibiting neutrophil rolling and tethering	€155.00
2825	PDE9A inhibitor C33(S)	Potent and selective PDE9A inhibitor	€135.00
3094	GLPG1690	First-in-class, potent ATX inhibitor	€110.00
3148	BPN14770	Potent, selective, allosteric inhibitor of PDE4D	€120.00
3169	Crisaborole	Potent PDE4 inhibitor; Anti-inflammatory agent	€60.00
3179	Pentoxifylline	Non-specific inhibitor of cAMP phosphodiesterases	€50.00
3289	GW4869 trifluoroacetate	Noncompetitive, neutral, magnesium-dependent SMase inhibitor	€65.00
3401	MBCQ	Potent and selective inhibitor of PDE5	€60.00
3574	Carbazeran	Potent phosphodiesterase inhibitor and an aldehyde oxidase (AO) substrate	€90.00
3889	Vinpocetine	Brain-penetrant PDE/IKK inhibitor; Na+ channel blocker	€50.00
4002	RS 25344	Selective PDE4 inhibitor	€130.00
4013	Piclamilast	Potent and selective PDE4 inhibitor	€130.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

Roflumilast - Daxas | BY 217 | BYK 20869 | B 9302-107

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

Roflumilast - Daxas | BY 217 | BYK 20869 | B 9302-107

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us