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Roflumilast
- Daxas - BY 217 - BYK 20869 - B 9302-107
- Soluble in DMSO
- MF: C17H14Cl2F2N2O3
- MW: 403.21
Description
More Information
| Parent CAS No. | 162401-32-3 |
|---|---|
| Chemical Name | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide |
| SMILES | C(NC1C(Cl)=CN=CC=1Cl)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 |
| MFCD | MFCD00938270 |
| InChi | InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) |
| InChiKey | MNDBXUUTURYVHR-UHFFFAOYSA-N |
| CID | 449193 |
| Short Description | PDE4 inhibitor |
References
- K.F. Rabe et al. Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Br. J. Pharmacol. 2011, 163, 53-67.
- W. Timmer et al. The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS-stimulated TNF-alpha ex vivo. J. Clin. Pharmacol. 2002, 42, 297-303.
- L.A. Sorbera et al. Roflumilast: antiallergy/antiasthmatic, treatment of COPD, phosphodiesterase 4 inhibitor. Drugs Fut. 2000, 25, 1261-1264.
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