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SC 144 hydrochloride
Axon 2324
- Parent CAS: 895158-95-9
Purity:
99%
- Soluble in DMSO
- MF: C16H111FN6O.HCl
- MW: 358.76
Description
The first-in-class small-molecule gp130 inhibitor with oral activity in ovarian cancer (IC50 values 0.43-0.95 µM for a range of human ovarian cancer cell lines). SC144 binds gp130, induces gp130 phosphorylation and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
More Information
| Parent CAS No. | 895158-95-9 |
|---|---|
| Chemical Name | N'-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide hydrochloride |
| SMILES | C1(C(NNC2=NC3=C(N4C=CC=C42)C=CC(F)=C3)=O)=NC=CN=C1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C16H11FN6O.ClH/c17-10-3-4-13-11(8-10)20-15(14-2-1-7-23(13)14)21-22-16(24)12-9-18-5-6-19-12;/h1-9H,(H,20,21)(H,22,24);1H |
| InChiKey | LKFGGXYXFIICED-UHFFFAOYSA-N |
| CID | 66921431 |
| Short Description | gp130 inhibitor |
References
- C. Plasencia et al. Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity. Cancer Biol Ther. 2009 Mar;8(5):458-65.
- S. Xu et al. Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol Cancer Ther. 2013 Jun;12(6):937-49.
- T. Oshima et al. Combination effects of SC144 and cytotoxic anticancer agents. Anticancer Drugs. 2009 Jun;20(5):312-20.
- F. Grande et al. Synthesis and antitumor activities of a series of novel quinoxalinhydrazides. Bioorg Med Chem. 2007 Jan 1;15(1):288-94.
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