Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2323

CAS [1099644-42-4]

MF C27H29NO3
MW 415.52

  • Purity: 98%
  • Soluble in DMSO



Selective inhibitor of TGFβ/Smad signaling (IC50 value 0.85 μM; 83% TGF-β inhibiton at 2.5 μM) that acts by clearing the type II TGFβ receptor from the cell surface. ITD1 stimulates the differentiation of cardiomyocytes and promote cardiogenesis in murine embryonic stem cell (mESCs). TGFβ inhibition by the (+)-eneatiomer is approximately 15-fold more effective than by its (−)-enantiomer.

Note: The optically pure (+)-ITD 1 (Axon 2467) is available as well

KEYWORDS: ITD 1 | supplier | TGF-βR2 inhibitor | ITD1 | CAS [1099644-42-4] | TGF-β | TGF-βR | Antagonist | Smad | type II | differentiation | cardiomyocytes | cardiogenesis | embryonic stem cell | mESCs

Size Unit Price Stock
10 mg €105.00 In Stock
50 mg €420.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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