Selective inhibitor of TGFβ/Smad signaling (IC50 value 0.85 μM; 83% TGF-β inhibiton at 2.5 μM) that acts by clearing the type II TGFβ receptor from the cell surface. ITD1 stimulates the differentiation of cardiomyocytes and promote cardiogenesis in murine embryonic stem cell (mESCs). TGFβ inhibition by the (+)-eneatiomer is approximately 15-fold more effective than by its (−)-enantiomer.

Note: The optically pure (+)-ITD 1 (Axon 2467) is available as well

KEYWORDS: ITD 1 | supplier | TGF-βR2 inhibitor | ITD1 | CAS [1099644-42-4] | TGF-β | TGF-βR | Antagonist | Smad | type II | differentiation | cardiomyocytes | cardiogenesis | embryonic stem cell | mESCs