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PPQ 102
Axon 2295
CAS:
931706-15-9
Purity:
99%
- Soluble in DMSO
- MF: C26H22N4O3
- MW: 438.48
Description
Potent CFTR inhibitor (IC50 value ca 90 nM in CFTR chloride conductance essay). PPQ 102 acts by a mechanism involving stabilization of the channel closed-state. Prevented cyst expansion and reduced the size of preformed cysts in an embryonic kidney organ culture model of Polycystic kidney disease (PKD).
More Information
| Parent CAS No. | 931706-15-9 |
|---|---|
| Chemical Name | 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione |
| SMILES | C12C(=O)N(C)C(=O)N(C)C1=C1C(C3OC(C)=CC=3)NC3C=CC=CC=3N1C=2C1C=CC=CC=1 |
| MFCD | MFCD14824240 |
| InChi | InChI=1S/C26H22N4O3/c1-15-13-14-19(33-15)21-24-23-20(25(31)29(3)26(32)28(23)2)22(16-9-5-4-6-10-16)30(24)18-12-8-7-11-17(18)27-21/h4-14,21,27H,1-3H3 |
| InChiKey | MNOOVRNGPIWJDI-UHFFFAOYSA-N |
| CID | 16016583 |
| Short Description | CFTR inhibitor |
References
- L. Tradtrantip et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J. Med. Chem. 2009, 52, 6447-6455.
- D.S. Snyder et al. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J. Med. Chem. 2011, 54, 5468-5477.
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