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AdipoRon
Axon 2275
CAS:
924416-43-3
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C27H28N2O3
- MW: 428.52
Description
Orally active small-molecule AdipoR agonist (Kd values 1.8 and 3.1 μM for AdipoR1 and AdipoR2 respectively) that exerts antidiabetic effects via activation of AMPK and PPAR-α pathways.AdipoRon ameliorated insulin resistance, glucose intolerance, and diabetes of genetically obese rodent model db/db mice, thereby prolonging the shortened lifespan of db/db mice on a high-fat diet.
More Information
| Parent CAS No. | 924416-43-3 |
|---|---|
| Chemical Name | 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide |
| SMILES | C(NC1CCN(CC2=CC=CC=C2)CC1)(=O)COC1=CC=C(C(=O)C2=CC=CC=C2)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30) |
| InChiKey | SHHUPGSHGSNPDB-UHFFFAOYSA-N |
| CID | 16307093 |
| Short Description | AdipoR agonist |
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