AZD 8797 - CX3CR1 antagonist 18a

Based on 4 publications in PubMed 10 10 4

Axon 2255

CAS [911715-90-7]

MF C19H25N5OS2
MW 403.56

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

AZD 8797

Description

Potent and selective antagonist of the Fractalkine receptor (FKN or CX3CR1; Ki value 3.9 nM) with a 720 fold selectivity over the CXCR2 receptor, a 246-fold selectivity versus hCCR1 and 187-fold versus hCCR2 and no significant antagonism of the CCR4, CCR5, CCR6, CXCR3, and CXCR5 receptors. 
AZD 8797 displayed adequate metabolic stability and solubility and high Caco-2 permeability.
Notably, AZD 8797 exhibited a significant interaction (>50% activity at 10 μM) for the adenosine A1 receptor only, and the selectivity was later determined to be 33-fold. 

KEYWORDS: AZD 8797 | supplier | CX3CR1 antagonist | CX3CR1 antagonist 18a | AZD8797 | CAS [911715-90-7] | Chemokine | Fractalkine | GPCR | FKN | CX3CR | Caco-2 permeability | migration | adhesion | extravasation | inflammatory | lymphocytes | leukocytes | multiple sclerosis

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2 mg €120.00 In Stock
5 mg €210.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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