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Axon 2255
CAS [911715-90-7]
MF C19H25N5OS2MW 403.56
Potent and selective antagonist of the Fractalkine receptor (FKN or CX3CR1; Ki value 3.9 nM) with a 720 fold selectivity over the CXCR2 receptor, a 246-fold selectivity versus hCCR1 and 187-fold versus hCCR2 and no significant antagonism of the CCR4, CCR5, CCR6, CXCR3, and CXCR5 receptors. AZD 8797 displayed adequate metabolic stability and solubility and high Caco-2 permeability. Notably, AZD8797 exhibited a significant interaction (>50% activity at 10 μM) for the adenosine A1 receptor only, and the selectivity was later determined to be 33-fold.
KEYWORDS: AZD8797 | Supplier | CX3CR1 antagonist | CX3CR1 antagonist 18a | KAND567 | AZD-8797 | AZD 8797 | KAND-567 | KAND 567 | CAS [911715-90-7] | Chemokine | Antagonist | Receptors | Fractalkine | GPCR | FKN | CX3CR | Caco-2 permeability | Migration | Adhesion | Extravasation | Inflammatory | Lymphocytes | Leukocytes | Multiple Sclerosis
(R)-2-(2-amino-5-((S)-1-phenylethylthio)thiazolo[4,5-d]pyrimidin-7-ylamino)-4-methylpentan-1-ol
[911715-90-7]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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