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GNF 5837

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2248

CAS [1033769-28-6]

MF C28H21F4N5O2
MW 535.49

  • Purity: 99%
  • Soluble in DMSO

GNF 5837

Description

Potent, selective, and orally bioavailable tropomyosin receptor kinase (TRK) inhibitor with efficacy in rodent cancer tumor models (IC50 values 11, 9, and 7 nM for TRK A, B and C respectively in cellular Ba/F3 assay). Up to 100% tumor regression was observed in tumor xenografts derived from RIE cells expressing both TRKA and NGF.
Potent, selective, and orally bioavailable tropomyosin receptor kinase (Trk) inhibitor

Chemical name

1-(3-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-ylamino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

Parent CAS No.

[1033769-28-6]

Order
Size Unit Price Stock
5 mg €90.00 In Stock
25 mg €300.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €480.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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