Your cart

There are no items in your shopping cart

GNF 5837

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2248

CAS [1033769-28-6]

MF C28H21F4N5O2
MW 535.49

  • Purity: 99%
  • Soluble in DMSO

GNF 5837

Description

Potent, selective, and orally bioavailable tropomyosin receptor kinase (TRK) inhibitor with efficacy in rodent cancer tumor models (IC50 values 11, 9, and 7 nM for TRK A, B and C respectively in cellular Ba/F3 assay). Up to 100% tumor regression was observed in tumor xenografts derived from RIE cells expressing both TRKA and NGF.
Potent, selective, and orally bioavailable tropomyosin receptor kinase (Trk) inhibitor

Chemical name

1-(3-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-ylamino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

Parent CAS No.

[1033769-28-6]

Order
Size Unit Price Stock
5 mg €90.00 In Stock
25 mg €300.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €480.00 In Stock
Need more? Bulk Inquiry

Related Products

Axon ID Name Description From price
1251 GW 441756 TrkA inhibitor €75.00
1610 AZ 23 TrkA and TrkB inhibitor €80.00
2089 7,8-Dihydroxyflavone Tyrosine kinase receptor B (TrkB) agonist €55.00
2174 PD90780 Inhibitor of NGFs binding to the P75 NGFR €110.00
2374 Optovin Reversible photoactivated TRPA1 agonist €85.00
2468 ANA 12 Selective TrkB antagonist with anxiolytic and antidepressant activity in mice €90.00
3407 LOXO-101 sulfate First-in-class, potent, highly selective and ATP-competitive TRK inhibitor €80.00
3775 TrkB agonist prodrug R13 Prodrug of 7,8-Dihydroxyflavone; TrkB agonist €120.00
3901 LOXO-195 Trk inhibitor Inquire
3998 MGCD516 Orally bioavailable receptor tyrosine kinase (RTK) inhibitor Inquire

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Newsletter
Give Feedback
 
Send E-mail

Customer Support

About Axon Medchem

Download Product Catalog

Download the Axon Ligands™ catalogue 2025 Spring Edition

Follow Us

© 2016 Axon Medchem. All Rights Reserved.

Send us a message

×

Contact Us

* Required Fields

Please wait...