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GNF 5837

Axon 2248
CAS:  1033769-28-6
Purity:  99%
  • Soluble in DMSO
  • MF:  C28H21F4N5O2
  • MW:  535.49

Description

Potent, selective, and orally bioavailable tropomyosin receptor kinase (TRK) inhibitor with efficacy in rodent cancer tumor models (IC50 values 11, 9, and 7 nM for TRK A, B and C respectively in cellular Ba/F3 assay). Up to 100% tumor regression was observed in tumor xenografts derived from RIE cells expressing both TRKA and NGF.

More Information

Certificate of Analysis

Material Safety Data Sheet

Parent CAS No. 1033769-28-6
Chemical Name 1-(3-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-ylamino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
SMILES C1C=C(F)C(NC(=O)NC2C=CC(C)=C(NC3C=CC4/C(=C/C5=CC=CN5)/C(=O)NC=4C=3)C=2)=CC=1C(F)(F)F
MFCD N.A.
InChi InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
InChiKey YYDUWLSETXNJJT-MTJSOVHGSA-N
CID 59397065
Short Description Trk inhibitor

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