Bulk Inquiry
NT 157
- Soluble in DMSO
- MF: C16H14BrNO5S
- MW: 412.26
Description
NT 157 is an allosteric inhibitor of IGF1R signaling that promotes ERK-MAPK-dependent inhibitory serine phosphorylation and degradation of insulin receptor substrate 1 and 2 (IRS1/2). It shifts IGF1R complex formation from IRS1/2 toward Shc, leading to sustained inhibition of IGF1R pathway output.
IGF1R/IRS signaling supports tumor growth, survival and resistance to targeted therapies. NT 157 is relevant for studying adaptor-level IGF1R pathway suppression, IRS degradation and resistance mechanisms in oncology models.
Key Features
- Allosteric inhibitor of IGF1R pathway signaling
- Promotes inhibitory serine phosphorylation of IRS1/2
- Drives degradation of insulin receptor substrates
- Suppresses tumor cell growth and resistance-associated signaling
Applications
- IGF1R signaling research
- IRS1/IRS2 degradation studies
- Oncology resistance model profiling
- ERK-MAPK pathway cross-talk assays
More Information
| Parent CAS No. | 1384426-12-3 |
|---|---|
| Chemical Name | (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide |
| SMILES | C(=S)(NCC1=CC(O)=C(O)C(O)=C1)/C=C/C1=CC(O)=C(O)C(Br)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H14BrNO5S/c17-10-3-8(4-11(19)15(10)22)1-2-14(24)18-7-9-5-12(20)16(23)13(21)6-9/h1-6,19-23H,7H2,(H,18,24)/b2-1+ |
| InChiKey | NIPUPOUEGOSAAO-OWOJBTEDSA-N |
| CID | 135398520 |
| Short Description | Allosteric inhibitor of IGF1R |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 4489 | I-OMe-Tyrphostin AG 538 |
From $154.00 |
| 1702 | OSI 906 |
From $66.00 |
| 1884 | Alectinib |
From $77.00 |
| 2267 | GSK 1838705A |
From $121.00 |
| 3341 | PQ401 |
From $110.00 |
| 3830 | GSK1904529A |
From Inquiry |
| 3973 | XL-228 |
From Inquiry |
