NT 157

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2238

CAS [1384426-12-3]

MF C16H14BrNO5S
MW 412.26

  • Purity: 99%
  • Soluble in DMSO

NT 157

Description

Unique allosteric inhibitor of IGF1R. NT 157 promotes ERK-MAPK dependent inhibitory Ser-phosphorylation and degradation of insulin receptor substrate 1 and 2 (IRS1/2) by shifting IGF1R complexation from IRS1/2 to Shc, which results in long-term inhibition of IGF1R signaling and powerful inhibition of tumor cell growth.
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2 mg €105.00 In Stock
5 mg €165.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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