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K 145 hydrochloride

Axon 2235

Parent CAS: 1309444-75-4

Purity: 99%

Soluble in water and DMSO

MF: C18H24N2O3S.HCl
MW: 384.92

Description

Selective, substrate competitive Sphingosine Kinase-2 inhibitor (SphK2; IC50 value 4.30 µM) and anticancer agent. K145 suppressed the S1P level, and significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration.K145 significantly inhibited the phosphorylation of FTY720, ERK and Akt upon treatment of U937 cells, but does not interfere with CERK and/or ceramide synthase.

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Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

SphK

Parent CAS No.	1309444-75-4
Chemical Name	3-(2-aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione hydrochloride
SMILES	S1/C(=CCCC2=CC=C(OCCCC)C=C2)/C(=O)N(CCN)C1=O.Cl
MFCD	N.A.
InChi	InChI=1S/C18H24N2O3S.ClH/c1-2-3-13-23-15-9-7-14(8-10-15)5-4-6-16-17(21)20(12-11-19)18(22)24-16;/h6-10H,2-5,11-13,19H2,1H3;1H/b16-6-;
InChiKey	HADFDMGQKBGVAV-NKBLJONXSA-N
CID	76849910
Short Description	SphK2 inhibitor

K 145 HCl SphK2 inhibitor Axon Medchem Axon 2235 K145 Sphingosine S1P sphinganine kinase Supplier Vendor

References

K. Liu et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One. 2013, 8, e56471.

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K 145 hydrochloride

Description

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