Your cart

There are no items in your shopping cart

K 145 hydrochloride

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2235

CAS [1449240-68-9]

MF C18H24N2O3S.HCl
MW 384.92

  • Purity: 99%
  • Soluble in water and DMSO

K 145 hydrochloride

Description

Selective, substrate competitive Sphingosine Kinase-2 inhibitor (SphK2; IC50 value 4.30 µM) and anticancer agent. K145 suppressed the S1P level, and significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration.K145 significantly inhibited the phosphorylation of FTY720, ERK and Akt upon treatment of U937 cells, but does not interfere with CERK and/or ceramide synthase.
Order
Size Unit Price Stock
10 mg €105.00 In Stock
50 mg €365.00 In Stock
Special Offers
Size Unit Price Stock
2 x 10 mg €160.00 In Stock
2 x 50 mg €580.00 In Stock
Need more? Bulk Inquiry

Related Products

Axon ID Name Description From price
1485 Fingolimod S1PR1 agonist; Immunosuppressant €60.00
1672 SEW 2871 S1PR1 agonist €80.00
1866 JTE 013 S1PR2 antagonist €130.00
1947 RP 001 hydrochloride A picomolar S1PR1 agonist €110.00
2350 PF 543 citrate Cell-permeant reversible inhibitor of SphK1 €99.00
2404 TY 52156 Selective, competitive, and orally active S1P3 antagonist €110.00
2484 K6PC-5 SphK1 (or SK1) activator that increases sphingosine-1-phosphate production €105.00
2782 SKI II Orally bioavailable SphK inhibitor €85.00
2880 ABC294640 Selective and orally available SphK2 (or SK2) inhibitor €125.00

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Newsletter
Give Feedback
 
Send E-mail

Customer Support

About Axon Medchem

Download Product Catalog

Download the Axon Ligands™ catalogue 2021 Spring Edition

Follow Us

© 2016 Axon Medchem. All Rights Reserved.

Send us a message

×

Contact Us

* Required Fields

Please wait...