K 145 hydrochloride

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2235

CAS [1449240-68-9]

MF C18H24N2O3S.HCl
MW 384.92

  • Purity: 99%
  • Soluble in water and DMSO

K 145 hydrochloride


Selective, substrate competitive Sphingosine Kinase-2 inhibitor (SphK2; IC50 value 4.30 µM) and anticancer agent. K145 suppressed the S1P level, and significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration.K145 significantly inhibited the phosphorylation of FTY720, ERK and Akt upon treatment of U937 cells, but does not interfere with CERK and/or ceramide synthase.
Size Unit Price Stock
10 mg €105.00 In Stock
50 mg €365.00 In Stock
Special Offers
Size Unit Price Stock
2 x 10 mg €160.00 In Stock
2 x 50 mg €580.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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