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LY 2940680
- Taladegib
Axon 2196
CAS:
1258861-20-9
Purity:
99%
- Soluble in DMSO
- MF: C26H24F4N6O
- MW: 512.5
Description
Small-molecule antagonist of the Smoothened (SMO) receptor (IC50 value 2.4 nM), a key signal transducer in the hedgehog signalling pathway, responsible for the maintenance of normal embryonic development and implicated in carcinogenesis. LY 2940680 lacks an undesired inhibitory effect on CYP3A4.
More Information
| Parent CAS No. | 1258861-20-9 |
|---|---|
| Chemical Name | 4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide |
| SMILES | C(N(C)C1CCN(C2=C3C(C=CC=C3)=C(C3N(C)N=CC=3)N=N2)CC1)(=O)C1=CC=C(F)C=C1C(F)(F)F |
| MFCD | MFCD21609264 |
| InChi | InChI=1S/C26H24F4N6O/c1-34(25(37)20-8-7-16(27)15-21(20)26(28,29)30)17-10-13-36(14-11-17)24-19-6-4-3-5-18(19)23(32-33-24)22-9-12-31-35(22)2/h3-9,12,15,17H,10-11,13-14H2,1-2H3 |
| InChiKey | SZBGQDXLNMELTB-UHFFFAOYSA-N |
| CID | 49848070 |
| Short Description | SMO antagonist |
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