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LY 2940680 - Taladegib

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2196

CAS [1258861-20-9]

MF C26H24F4N6O
MW 512.50

  • Purity: 99%
  • Soluble in DMSO

LY 2940680

Description

Small-molecule antagonist of the Smoothened (SMO) receptor (IC50 value 2.4 nM), a key signal transducer in the hedgehog signalling pathway, responsible for the maintenance of normal embryonic development and implicated in carcinogenesis. LY 2940680 lacks an undesired inhibitory effect on CYP3A4.
C. Wang et al. Structure of the human smoothened receptor bound to an antitumour agent. Nature. 2013, 497, 338-343. 
 
P.A. Hipskind et al. Preparation of disubstituted phthalazine derivatives for use as hedgehog pathway antagonists and useful in treatment of cancer. PCT Int. Appl. WO 2010147917 A1 20101223.
Small-molecule antagonist of the Smoothened (SMO) receptor

Chemical name

4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide

Parent CAS No.

[1258861-20-9]

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Size Unit Price Stock
5 mg €120.00 In Stock
25 mg €420.00 In Stock
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Size Unit Price Stock
2 x 5 mg €180.00 In Stock
2 x 25 mg €620.00 In Stock
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2356 BMS 833923 Oral antagonist of the Hedgehog signaling component Smoothened (SMO) €75.00
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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