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Fluphenazine decanoate dihydrochloride
- Prolixin Decanoate dihydrochloride
- Parent CAS: 5002-47-1
- Soluble in DMSO
- MF: C32H44F3N3O2S.2HCl
- MW: 664.69
Description
Fluphenazine decanoate dihydrochloride is a phenothiazine antipsychotic prodrug that releases fluphenazine and displays high-affinity dopamine D2/D3 receptor antagonism together with 5-HT2 receptor activity. Reported Ki values include 0.2 nM for D2, 0.11 nM for D3 and 2.0 nM for 5-HT2 receptors.
Dopamine D2-family blockade is central to antipsychotic pharmacology and motor/endocrine side-effect biology. Fluphenazine decanoate is relevant for long-acting antipsychotic mechanism studies and receptor-binding comparisons across dopaminergic and serotonergic systems.
Key Features
- High-affinity D2 and D3 receptor antagonist
- Phenothiazine antipsychotic pharmacology profile
- Also interacts with 5-HT2 receptors
- Useful reference for long-acting dopamine antagonist research
Applications
- Dopamine receptor pharmacology
- Antipsychotic mechanism studies
- D2/D3 binding assay comparison
- CNS drug-discovery model research
More Information
| Parent CAS No. | 5002-47-1 |
|---|---|
| Chemical Name | 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl decanoate dihydrochloride |
| SMILES | C(OCCN1CCN(CCCN2C3=CC(C(F)(F)F)=CC=C3SC3=C2C=CC=C3)CC1)(=O)CCCCCCCCC.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C32H44F3N3O2S.2ClH/c1-2-3-4-5-6-7-8-14-31(39)40-24-23-37-21-19-36(20-22-37)17-11-18-38-27-12-9-10-13-29(27)41-30-16-15-26(25-28(30)38)32(33,34)35;;/h9-10,12-13,15-16,25H,2-8,11,14,17-24H2,1H3;2*1H |
| InChiKey | IJIYWOFSPALWMA-UHFFFAOYSA-N |
| CID | 24745024 |
| Short Description | Antipsychotic; D2/D3/5-HT2 antagonist Antipsychotic with high affinity for dopamine and serotonin receptors |
References
- H.L. Yale et al. Esters of 4-{3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl}-1-piperazineëthanol as long-acting tranquilizing agents. Synthesis of... J. Med. Chem., 1963, 6, 347-350.
- P. Seeman et al. Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Mol. Psychiatry. 1998, 3, 123-134.
- B.L. Roth et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J. Pharmacol. Exp. Ther. 1994, 268, 1403-1410.
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