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VU 0255035
- ML012
- Soluble in DMSO
- MF: C18H20N6O3S2
- MW: 432.52
Description
VU 0255035 is a highly selective M1 muscarinic acetylcholine receptor antagonist with a Ki value of 14.87 nM.
M1 receptor signaling contributes to cognition, cortical excitability and cholinergic neurotransmission. VU 0255035 is useful for blocking M1-dependent responses and profiling muscarinic receptor subtype selectivity.
Key Features
- Selective antagonist of M1 muscarinic receptors
- Ki: 14.87 nM
- Useful for CHRM1 receptor blockade
- Small-molecule tool for cholinergic GPCR studies
Applications
- M1 receptor pharmacology
- Cholinergic neurotransmission assays
- Muscarinic antagonist selectivity profiling
- CNS receptor signaling studies
More Information
| Parent CAS No. | 1135243-19-4 |
|---|---|
| Chemical Name | N-(3-oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide |
| SMILES | N1=C2C=CC=C(S(NCCC(=O)N3CCN(C4C=CN=CC=4)CC3)(=O)=O)C2=NS1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H20N6O3S2/c25-17(24-12-10-23(11-13-24)14-4-7-19-8-5-14)6-9-20-29(26,27)16-3-1-2-15-18(16)22-28-21-15/h1-5,7-8,20H,6,9-13H2 |
| InChiKey | WXDHQWPQLKGANZ-UHFFFAOYSA-N |
| CID | 24768606 |
| Short Description | M1 antagonist |
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