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MG 149
- Soluble in DMSO
- MF: C22H28O3
- MW: 340.46
Description
MG149 is a novel anacardic acid analog and potent, selective MYST family histone acetyltransferase (HAT) inhibitor targeting Tip60 and MOZ. MG149 also effectively inhibits acetyltransferase activity in HeLa cell nuclear extracts, making it a useful tool for studying histone acetylation and chromatin regulation.
MYST family histone acetyltransferases regulate chromatin structure, transcriptional control, DNA damage response, cell cycle progression, and inflammatory gene expression. By inhibiting Tip60 and MOZ-dependent acetyltransferase activity, MG149 provides a valuable chemical probe for epigenetics, transcriptional regulation, inflammation, and cancer biology research.
Key Features
- Selective MYST family HAT inhibitor
- Targets Tip60 and MOZ acetyltransferases
- Novel anacardic acid analog
- Inhibits acetyltransferase activity in HeLa nuclear extracts
- Useful tool for histone acetylation and epigenetics research
Applications
- Histone acetyltransferase research
- Tip60 and MOZ biology studies
- Epigenetics and chromatin regulation research
- Transcriptional regulation and inflammation studies
- DNA damage response and cancer biology investigations
Scientific Origin
MG149 is supplied by Axon Medchem in collaboration with the University of Groningen (RuG).
More Information
| Parent CAS No. | 1243583-85-8 |
|---|---|
| Chemical Name | 2-(4-heptylphenethyl)-6-hydroxybenzoic acid |
| extra_info | Sold in collaboration with RuG (University of Groningen) |
| SMILES | C1C(O)=C(C(=O)O)C(CCC2C=CC(CCCCCCC)=CC=2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H28O3/c1-2-3-4-5-6-8-17-11-13-18(14-12-17)15-16-19-9-7-10-20(23)21(19)22(24)25/h7,9-14,23H,2-6,8,15-16H2,1H3,(H,24,25) |
| InChiKey | WBHQYBZRTAEHRR-UHFFFAOYSA-N |
| CID | 49864204 |
| Short Description | Tip60 HAT inhibitor |
References
- M Ghizzoni et al. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur. J. Med. Chem. 2012, 47(1), 337-344.
- FJ Dekker et al. Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases. Drug Discov Today. 2014 May;19(5):654-60.
- F Mo et al. Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nat Chem Biol. 2016 Apr;12(4):226-32.
- S Cregan et al. KAT5 (Tip60) is a potential therapeutic target in malignant pleural mesothelioma. Int J Oncol. 2016 Mar;48(3):1290-6.
- List of publications using MG 149 (Axon 1785) purchased from Axon Medchem
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