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KO 143
- Soluble in DMSO and EtOH
- MF: C26H35N3O5
- MW: 469.57
Description
Potent and selective inhibitor of breast cancer resistance protein (BCRP) multidrug transporter.
More Information
| Parent CAS No. | 461054-93-3 |
|---|---|
| Chemical Name | 3-((3S,6S,12aS)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)-propionic acid tert-butylester |
| MFCD | MFCD11042273 |
| Short Description | BCRP inhibitor |
References
- JD Allen et al. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Mol Cancer Ther. 2002 Apr;1(6):417-25.
- A van Loevezijn et al. Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines. Bioorg Med Chem Lett. 2001 Jan 8;11(1):29-32.
- List of publications using KO143 (Axon 1409) purchased from Axon Medchem
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