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Tariquidar
- XR 9576
Axon 1960
CAS:
206873-63-4
Purity:
98%
- Soluble in DMSO
- MF: C38H38N4O6
- MW: 646.73
Description
Potent and specific inhibitor of P-glycoprotein (P-gp, ABCB1); also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2).
More Information
| Parent CAS No. | 206873-63-4 |
|---|---|
| Chemical Name | N-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenylcarbamoyl)-4,5-dimethoxyphenyl)quinoline-3-carboxamide |
| SMILES | N1C2C(=CC=CC=2)C=C(C(NC2=CC(OC)=C(OC)C=C2C(NC2=CC=C(CCN3CCC4=C(C3)C=C(OC)C(OC)=C4)C=C2)=O)=O)C=1 |
| MFCD | MFCD09837824 |
| InChi | InChI=1S/C38H38N4O6/c1-45-33-18-25-14-16-42(23-28(25)19-34(33)46-2)15-13-24-9-11-29(12-10-24)40-38(44)30-20-35(47-3)36(48-4)21-32(30)41-37(43)27-17-26-7-5-6-8-31(26)39-22-27/h5-12,17-22H,13-16,23H2,1-4H3,(H,40,44)(H,41,43) |
| InChiKey | LGGHDPFKSSRQNS-UHFFFAOYSA-N |
| CID | 148201 |
| Short Description | P-gp inhibitor |
References
- E Fox, SE Bates. Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor. Expert Rev. Anticancer Ther. 2007, 7(4), 447-459.
- I. Leitner et al. The third-generation P-glycoprotein inhibitor tariquidar may overcome bacterial multidrug resistance by increasing intracellular drug concentration. J. Antimicrob. Chemother. 2011, 66(4), 834-839.
- P Kannan et al. The “Specific” P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2). ACS Chem. Neurosci., 2011, 2(2), 82–89.
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