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CP 100356 hydrochloride
- Parent CAS: 142716-85-6
- Soluble in DMSO
- MF: C31H36N4O6.HCl
- MW: 597.1
Description
CP 100356 hydrochloride is a potent P-glycoprotein (P-gp/ABCB1) inhibitor with reported Ki values of 58 and 94 nM for the 1a and 1b P-gp isomers.
ATP-binding cassette transporters such as P-gp and BCRP regulate drug disposition, barrier penetration and multidrug resistance. CP 100356 is applied as a probe compound to assess transporter-mediated efflux and pharmacokinetic liabilities.
Key Features
- Potent inhibitor of P-gp/ABCB1-mediated efflux
- Reported Ki values: 58 and 94 nM for P-gp isomers
- Useful in MDR1/BCRP transporter studies
- Supports assessment of drug transport and exposure
Applications
- Drug efflux and transporter assay development
- Multidrug resistance research
- Blood-brain barrier transport studies
- Pharmacokinetic interaction and substrate profiling
More Information
| Parent CAS No. | 142716-85-6 |
|---|---|
| Chemical Name | 4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3,4-dimethoxyphenethyl)-6,7-dimethoxyquinazolin-2-amine |
| SMILES | N(C1=NC2=CC(OC)=C(OC)C=C2C(N2CCC3=CC(OC)=C(OC)C=C3C2)=N1)CCC1C=CC(OC)=C(OC)C=1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C31H36N4O6.ClH/c1-36-24-8-7-19(13-25(24)37-2)9-11-32-31-33-23-17-29(41-6)28(40-5)16-22(23)30(34-31)35-12-10-20-14-26(38-3)27(39-4)15-21(20)18-35;/h7-8,13-17H,9-12,18H2,1-6H3,(H,32,33,34);1H |
| InChiKey | WWCHXVYTCMPAMV-UHFFFAOYSA-N |
| CID | 71312025 |
| Short Description | P-gp inhibitor |
References
- C Wandel et al. P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. 1999, 59, 3944.
- JC Taylor et al. The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar. Br. J. Cancer 1999, 81(5), 783-789.
- AS Kalgutkar et al. N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" (...). J. Pharm. Sci. 2009, 98, 4914.
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