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Zosuquidar trihydrochloride
- LY335979
- Parent CAS: 167354-41-8
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C32H31F2N3O2.3HCl
- MW: 636.99
Description
Zosuquidar trihydrochloride (LY335979) is a high-affinity and selective P-glycoprotein (P-gp/ABCB1) inhibitor with a reported Ki value of 59 nM.
P-gp is an ATP-binding cassette efflux transporter that limits intracellular drug accumulation and contributes to multidrug resistance and blood-brain barrier drug exclusion. Zosuquidar is used to study transporter-mediated pharmacokinetics and MDR reversal.
Key Features
- Selective P-gp/ABCB1 inhibitor
- Reported Ki: 59 nM
- Blocks ATP-dependent drug efflux
- Useful for multidrug resistance and transporter pharmacology research
Applications
- P-gp/ABCB1 efflux transporter assays
- Multidrug resistance reversal studies
- Drug accumulation and permeability models
- Blood-brain barrier transport research
More Information
| Parent CAS No. | 167354-41-8 |
|---|---|
| Chemical Name | (αR)-1-Piperazineethanol, 4-[(1aα,6α,10bα)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-, trihydrochloride |
| SMILES | C12C=CC=CC=1[C@H]1C(F)(F)[C@H]1C1C=CC=CC=1[C@@H]2N1CCN(C[C@@H](O)COC2C=CC=C3N=CC=CC=23)CC1.Cl.Cl.Cl |&1:6,10,17,23,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C32H31F2N3O2.3ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;;;/h1-14,21,29-31,38H,15-20H2;3*1H/t21-,29?,30?,31?;;;/m1.../s1 |
| InChiKey | ZPFVQKPWGDRLHL-YDHOSPECSA-N |
| CID | 91826483 |
| Short Description | P-gp inhibitor |
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