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PGP-4008
Axon 3784
CAS:
365565-02-2
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C26H23N3O
- MW: 393.48
Description
PGP-4008 is a selective P-glycoprotein (Pgp) inhibitor without modulating multidrug resistance-related protein 1 (MRP1). PGP-4008 inhibited tumor growth in a murine syngeneic Pgp-mediated MDR solid tumor model when given in combination with doxorubicin.
More Information
| Parent CAS No. | 365565-02-2 |
|---|---|
| Chemical Name | N-(1-Benzyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide |
| SMILES | C1C=C2C(NC(=O)CC3C=CC=CC=3)=C3CCN(CC4C=CC=CC=4)C3=NC2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C26H23N3O/c30-24(17-19-9-3-1-4-10-19)28-25-21-13-7-8-14-23(21)27-26-22(25)15-16-29(26)18-20-11-5-2-6-12-20/h1-14H,15-18H2,(H,27,28,30) |
| InChiKey | HVIAKQBMYMKWII-UHFFFAOYSA-N |
| CID | 9821937 |
| Short Description | P-gp inhibitor |
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