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SKF 83566 hydrobromide
- Parent CAS: 99295-33-7
- Soluble in water and DMSO
- MF: C17H18BrNO.HBr
- MW: 413.15
Description
SKF 83566 hydrobromide is a selective dopamine D1-like receptor antagonist used to block D1/D5 receptor-mediated signaling.
D1-like dopamine receptors regulate cAMP production, motor control, reward signaling and cognition-related pathways. SKF 83566 is useful for distinguishing D1-like receptor responses from D2-like dopaminergic signaling.
Key Features
- Selective D1-like dopamine receptor antagonist
- Blocks D1/D5-mediated dopaminergic signaling
- Useful for cAMP-linked dopamine receptor studies
- Supports D1 versus D2 pathway discrimination
Applications
- Dopamine D1 receptor pharmacology
- Dopaminergic signaling assays
- Motor and reward circuitry research
- CNS receptor selectivity profiling
More Information
| Parent CAS No. | 99295-33-7 |
|---|---|
| Chemical Name | 8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol hydrobromide |
| SMILES | C12C=C(C(Br)=CC=1CCN(C)CC2C1C=CC=CC=1)O.Br |
| MFCD | MFCD04039787 |
| InChi | InChI=1S/C17H18BrNO.BrH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H |
| InChiKey | SDQJYYGODYRPBR-UHFFFAOYSA-N |
| CID | 23581817 |
| Short Description | D1 antagonist |
References
- R Pedrosa et al. Defective D1-like receptor-mediated inhibition of the Cl–/HCO3– exchanger in immortalized SHR proximal tubular epithelial cells. Am. J. Physiol. Renal. Physiol. 2004, 286, F1120-F1126.
- Meyeret al. Effects of dopamine D1 antagonists SCH23390 and SK&F83566 on locomotor activities in rats. Pharmacol. Biochem. Behav. 1993, 44, 429.
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