Bulk Inquiry
SB 590885
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C27H27N5O2
- MW: 453.54
Description
Potent and selective inhibitor of B-Raf kinase (Kd value 0.3 nM for BRAF), devoid of significant activity against a wide panel of enzymes, including p38α, GSK3β, and Lck. SB590885 maintains OCT4-ΔPE-GFP reporter activity and pluripotency gene expression in human ESCs after removal of exogenous KLF2 and NANOG expression, preserving the best colony morphology and proliferation.
SB 590885 is frequently used in a combination of five compounds, including inhibitors of MEK, GSK-3β, BRAF, ROCK, and SRC, which support the expansion of viable OCT4-ΔPE-GFP+ human pluripotent cells after exogenous transcription factor expression has been removed:
| Axon 2504 | SB 590885 | BRAF inhibitor |
| Axon 2511 | IM 12 | GSK-3β inhibitor |
| Axon 1408 | PD 0325901 | MEK inhibitor |
| Axon 1683 | Y 27632 | ROCK inhibitor |
| Axon 2381 | WH4-023 | Lck/Src inhibitor |
(alternatively, CHIR99021 (Axon 1386) could be used as GSK-3β inhibitor)
Naive Stem Cell 5i inhibitor Set is commercially available (Axon 5011)
More Information
| Parent CAS No. | 405554-55-4 |
|---|---|
| Chemical Name | 5-(2-(4-(2-(dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime |
| SMILES | C1(=N/O)C2=C(C=C(C3=C(C4C=CN=CC=4)NC(C4=CC=C(OCCN(C)C)C=C4)=N3)C=C2)CC1 |
| MFCD | MFCD16038645 |
| InChi | InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,33H,6,10,15-16H2,1-2H3,(H,29,30)/b31-24+ |
| InChiKey | MLSAQOINCGAULQ-QFMPWRQOSA-N |
| CID | 135421339 |
| Short Description | BRAF inhibitor |
References
- T.W. Theunissen et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell. 2014 Oct 2;15(4):471-87.
- A.K. Takle et al. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81.
- A.J. King et al. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res. 2006 Dec 1;66(23):11100-5.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1397 | Sorafenib tosylate |
From $77.00 |
| 1459 | GDC 0879 |
From $77.00 |
| 1474 | PLX 4720 |
From $55.00 |
| 1545 | AZ 628 |
From $88.00 |
| 1624 | PLX 4032 |
From $66.00 |
| 1984 | GW 5074 |
From $93.50 |
| 2590 | Locostatin |
From $66.00 |
| 2651 | OAC2 |
From $66.00 |
| 2817 | RAF709 |
From $132.00 |
| 3067 | Belvarafenib |
From $126.50 |
| 3351 | Sorafenib |
From $66.00 |
| 3556 | LXH254 |
From $198.00 |
| 3862 | BGB-283 |
From Inquiry |
| 4033 | TAK-632 |
From Inquiry |
| 5011 | Naive Stem Cell 5i inhibitor Set |
From $220.00 |
Other Categories
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.